Journal article
Bond graph modelling of chemoelectrical energy transduction
PJ Gawthrop, I Siekmann, T Kameneva, S Saha, MR Ibbotson, EJ Crampin
Iet Systems Biology | INST ENGINEERING TECHNOLOGY-IET | Published : 2017
Abstract
Energy-based bond graph modelling of biomolecular systems is extended to include chemoelectrical transduction thus enabling integrated thermodynamically compliant modelling of chemoelectrical systems in general and excitable membranes in particular. Our general approach is illustrated by recreating a well-known model of an excitable membrane. This model is used to investigate the energy consumed during a membrane action potential thus contributing to the current debate on the trade-offbetween the speed of an action potential event and energy consumption. The influx of Na+ is often taken as a proxy for energy consumption; in contrast, this study presents an energy-based model of action potent..
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Awarded by Sonderforschungsbereich (SFB), (Deutsche Forschungsgemeinschaft, Germany)
Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology
Funding Acknowledgements
We thank the reviewers for their suggestions for improving the paper. P.G. thank the Melbourne School of Engineering for its support via a Professorial Fellowship. I.S. gratefully acknowledges funding from Sonderforschungsbereich (SFB) 803, project Z02 (Deutsche Forschungsgemeinschaft, Germany). This research was in part conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036).